Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

Neurological disorders (NDs) are one of the leading causes of global death. A sustained
neuroinflammatory response has been reported to be associated with the pathogenesis of …

Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes
pain and disability. Many of the currently available drugs for treating RA patients are aimed …

Abstract Chemokine (C–C) ligand 17 (CCL17) was first identified as thymus‐and activation‐
regulated chemokine when it was found to be constitutively expressed in the thymus and …

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …

Cytokine-mediated STAT5 protein activation is vital for lymphocyte development and
function. In vitro tyrosine phosphorylation of a C-terminal tyrosine is critical for activation of …

JAK/STAT signaling pathways are closely associated with multiple biological processes
involved in cell proliferation, apoptosis, inflammation, differentiation, immune response, and …

Inflammatory reaction after ischemia-reperfusion contributes significantly to a worsened
prognosis, and microglia activation is the main resource of inflammation in the nervous …

In response to external stimuli during immune responses, monocytes can have multifaceted
roles such as pathogen clearance and tissue repair. However, aberrant control of monocyte …

Relapsing‐remitting multiple sclerosis is associated with changes in Jak/STAT pathways in
immune cells, but the influence of disease‐modifying drugs on these pathways is poorly …