[HTML][HTML] Clinical-pathologic challenges in the classification of pulmonary neuroendocrine neoplasms and targets on the horizon for future clinical practice
JL Derks, N Rijnsburger, BCM Hermans… - Journal of Thoracic …, 2021 - Elsevier
Diagnosing a pulmonary neuroendocrine neoplasm (NEN) may be difficult, challenging
clinical decision making. In this review key clinical and pathological issues and informative …
clinical decision making. In this review key clinical and pathological issues and informative …
Molecular pathology of well-differentiated pulmonary and thymic neuroendocrine tumors: what do pathologists need to know?
Thoracic (pulmonary and thymic) neuroendocrine tumors are well-differentiated epithelial
neuroendocrine neoplasms that are classified into typical and atypical carcinoid tumors …
neuroendocrine neoplasms that are classified into typical and atypical carcinoid tumors …
Prognostic significance of laterality in lung neuroendocrine tumors
A La Salvia, I Persano, A Siciliani, M Verrico, M Bassi… - Endocrine, 2022 - Springer
Purpose: Well-differentiated lung neuroendocrine tumors (Lu-NET) are classified as typical
(TC) and atypical (AC) carcinoids, based on mitotic counts and necrosis. However …
(TC) and atypical (AC) carcinoids, based on mitotic counts and necrosis. However …
Pulmonary neuroendocrine neoplasms with well differentiated morphology and high proliferative activity: illustrated by a case series and review of the literature
BCM Hermans, JL Derks, L Moonen, CHJ Habraken… - Lung Cancer, 2020 - Elsevier
Abstract Objectives Pulmonary neuroendocrine neoplasms (NENs) are subdivided in
carcinoids and neuroendocrine carcinomas (small cell lung carcinoma and large cell …
carcinoids and neuroendocrine carcinomas (small cell lung carcinoma and large cell …
Clinic and genetic similarity assessments of atypical carcinoid, neuroendocrine neoplasm with atypical carcinoid morphology and elevated mitotic count and large cell …
Y Zhang, W Wang, Q Hu, Z Liang, P Zhou, Y Tang… - BMC cancer, 2022 - Springer
Background Pulmonary neuroendocrine neoplasms can be divided into typical carcinoid,
atypical carcinoid, large cell neuroendocrine carcinoma, and small cell (lung) carcinoma …
atypical carcinoid, large cell neuroendocrine carcinoma, and small cell (lung) carcinoma …
Neuroendocrine tumor G3 of bronchopulmonary origin and its classification
A Kasajima, G Klöppel - Pathology International, 2022 - Wiley Online Library
Neuroendocrine tumors (NET) with high proliferative activity (Ki‐67 index> 20% and/or
mitotic counts> 2 mm2) are defined as NET G3 in the 2019 World Health Organization …
mitotic counts> 2 mm2) are defined as NET G3 in the 2019 World Health Organization …
Beyond traditional morphological characterization of lung neuroendocrine neoplasms: In silico study of next-generation sequencing mutations analysis across the four …
G Centonze, D Biganzoli, N Prinzi, S Pusceddu… - Cancers, 2020 - mdpi.com
Simple Summary Lung neuroendocrine neoplasms (LNENs) classes, as proposed by the
World Health Organization 2015, do not provide properly prognostic and therapeutic …
World Health Organization 2015, do not provide properly prognostic and therapeutic …
Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor
M Li, Y Zhang, P Zhou, Y Miao, S Li, L Jiang - Lung Cancer, 2024 - Elsevier
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a highly aggressive neoplasm
with biological heterogeneity. Mutations in multiple genes have been identified in LCNEC …
with biological heterogeneity. Mutations in multiple genes have been identified in LCNEC …
Diagnostic relevance of p53 and Rb status in neuroendocrine tumors G3 from different organs: an immunohistochemical study of 465 high-grade neuroendocrine …
The double inactivation of TP53 and RB1 is considered typical of neuroendocrine
carcinomas (NECs) but is assumed to be rare in high-grade neuroendocrine tumors (NETs) …
carcinomas (NECs) but is assumed to be rare in high-grade neuroendocrine tumors (NETs) …
Exploring the molecular features and genetic prognostic factors of pulmonary high-grade neuroendocrine carcinomas
H Wang, L Yan, Y Zhu, W Sun, X Yang, X Liu, K Chi… - Human Pathology, 2023 - Elsevier
Molecular research on large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung
cancer (SCLC) has progressed significantly. However, there are still fewer molecular …
cancer (SCLC) has progressed significantly. However, there are still fewer molecular …