The identification and optimization of lead compounds are inalienable components in drug
design and discovery pipelines. As a powerful computational approach for the identification …

Highlights•Tau plays an important part in the formation of axonal microtubules.•
Phosphorylated tau (P-tau) plays an aberrant part in causing Alzheimer's disease.•P-tau is a …

Most recently, the new coronavirus (SARS-CoV-2) has been recognized as a pandemic by
the World Health Organization (WHO) while this virus shares substantial similarity with …

Alzheimer's disease is a progressive neurodegenerative disorder and as the exact cause of
the disease remains unknown, it still has no cure to date. Due to the fact that, until recently …

Memory impairment is a result of multiple factors including amyloid-beta (Aβ) accumulation.
Several receptors are mediated for Aβ transport and signaling. Moreover, blood lipids are …

Acetylcholinesterase (AChE) is an important enzyme and target for human therapeutics,
environmental safety, and global food supply. Inhibitors of this enzyme are also used for pest …

Cisplatin is administrated as an agent in treatment of various cancers by intercalation
between DNA strands and inhibition of DNA replication. Among the various factors, two …

Doublecortin‑like kinase protein 1 (DCLK1) is a microtubule‑associated protein with a C‑
terminal serine/threonine kinase domain. Its expression was first reported in radial glial cells …

Alzheimer's disease (AD) is a prevalent neurodegenerative condition characterized by
progressive cognitive decline and memory impairment resulting from the degeneration and …

Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease, demands
effective medication to alleviate symptoms. This study focused on sleep impairment as an …