Natural killer cells (NK) represent a population of lymphocytes involved in innate immune
response. In addition to their role in anti-viral and anti-tumor defense, they also regulate …

The mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cellular
metabolism and also has fundamental roles in controlling immune responses. Emerging …

The mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved
serine/threonine kinase which is a member of the PI3K related kinase (PIKK) family. mTOR …

The role of Natural killer (NK) cells during kidney allograft antibody–mediated rejection
(ABMR) is increasingly recognized, but an in-depth characterization of mechanisms that …

Isolated microvascular inflammation (iMVI) without HLA donor-specific antibodies or C4d
deposition in peritubular capillaries remains an enigmatic phenotype that cannot be …

Allograft rejection constitutes a major complication of solid organ transplantation requiring
prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to …

Small-molecule immunosuppressive drugs (ISD) prevent graft rejection mainly by inhibiting
T lymphocytes. Therapeutic immunoglobulins (IVIg) are used for substitution, antibody …

Detection of posttransplant donor-specific anti-HLA antibodies (DSA) constitutes a risk factor
for kidney allograft loss. Together with complement activation, NK-cell antibody-dependent …

In this study, an impaired natural killer (NK) cell cytolytic activity in 135 hepatocellular
carcinoma (HCC) patients parallel to a reduced expression level of insulin-like growth factor …

Human cytomegalovirus (HCMV) reactivation remains a relevant complication after
hematopoietic stem cell transplantation (HSCT) despite the great progress made in …