Chemical Tools for the Study of DNA Repair

YW Jun, ET Kool - Accounts of chemical research, 2022 - ACS Publications
Conspectus DNA repair enzymes continuously provide surveillance throughout our cells,
protecting the enclosed DNA from the damage that is constantly arising from oxidation …

An inosine triphosphate pyrophosphatase safeguards plant nucleic acids from aberrant purine nucleotides

H Straube, J Straube, J Rinne, L Fischer… - New …, 2023 - Wiley Online Library
In plants, inosine is enzymatically introduced in some tRNAs, but not in other RNAs or DNA.
Nonetheless, our data show that RNA and DNA from Arabidopsis thaliana contain (deoxy) …

Human mitochondrial protein hspd1 binds to and regulates the repair of deoxyinosine in DNA

X Zheng, S Chang, Y Liu, X Dai… - Journal of Proteome …, 2023 - ACS Publications
The generation of deoxyinosine (dI) in DNA is one of the most important sources of genetic
mutations, which may lead to cancer and other human diseases. A further understanding of …

Occupational exposure to metal-rich particulate matter modifies the expression of repair genes in foundry workers

Z Panjali, O Hahad, F Rajabi… - Toxicology and …, 2021 - journals.sagepub.com
Foundry workers are exposed to numerous occupational health hazards, which may result in
increased risk of cancer, respiratory disease, and other diseases. Oxidative stress is known …

Structure–function analysis of nucleotide housekeeping protein HAM1 from human malaria parasite Plasmodium falciparum

D Saha, A Pramanik, A Freville, AA Siddiqui… - The FEBS …, 2024 - Wiley Online Library
Non‐canonical nucleotides, generated as oxidative metabolic by‐products, significantly
threaten the genome integrity of Plasmodium falciparum and thereby, their survival, owing to …

[PDF][PDF] Mass spectrometry-based metabolomic profiling of prostate cancer-a pilot study

K Ossoliński, J Nizioł, A Arendowski… - J. Cancer …, 2019 - pdfs.semanticscholar.org
Abstract Aim: Prostate cancer (PCa) is the most commonly diagnosed non-skin cancer
among men. Serum prostatespecific antigen level is used as a standard PCa biomarker for …

Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.

SG Kozmin, IB Rogozin, EA Moore, M Abney… - Science …, 2019 - science.org
A recent article in Science Advances described the striking discovery that the commensal
Staphylococcus epidermidis strain MO34 displays antimicrobial and antitumor activities by …

ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions

P Wanat, R Kasprzyk, M Kopcial, PJ Sikorski… - Chemical …, 2018 - pubs.rsc.org
We describe a new type of nucleotide-derived fluorescent probe designed for monitoring
pyrophosphatase activity based on excimer-to-monomer transitions, called ExciTide. The …

ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase

D Ji, AM Kietrys, Y Lee, ET Kool - Bioconjugate chemistry, 2018 - ACS Publications
Nucleotide surveillance enzymes play important roles in human health, by monitoring
damaged monomers in the nucleotide pool and deactivating them before they are …

[PDF][PDF] Human Cryptochrome Mediates Oxidative Stress Responses Modulated by Static and Electromagnetic Fields in Doxorubicin-Treated Cells

B Hajipour-Verdom, M Alipour, P Abdolmaleki… - 2020 - academia.edu
Cryptochromes (CRYs) have been suggested to involve in the magnetic sensing for
navigation of migratory birds in response to Earth's magnetic elds. Magnetic elds (MFs) …