Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Most chronic diseases, caused by lifestyle factors, appear to be linked to inflammation.
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …

Regulation of immune function continues to be one of the most well recognized extraskeletal
actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells …

Each year ecotoxicological problems become increasingly complex and encompass
broader spatial and temporal scales. Our practical understanding must evolve accordingly to …

COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …

Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …

Personalized medicine strives to optimize drug treatment for the individual patient by taking
into account both genetic and non-genetic factors for drug response. Inflammation is one of …

Low-molecular-weight chemicals or xenobiotics might contribute to the increasing
prevalence of allergies and autoimmunity. Certain chemicals can alter immune responses …

This article is a report on a symposium sponsored by the American Society for
Pharmacology and Experimental Therapeutics and held at the Experimental Biology 07 …

BACKGROUND: Benzo (a) pyrene (BaP) is an environmental contaminant found in cigarette
smoke. It is well known that cigarette smoking exacerbates interleukin-8 (IL-8)-related …