In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …

The repeated failures of amyloid-targeting therapies have challenged our narrow
understanding of Alzheimer's disease (AD) pathogenesis and inspired wide-ranging …

Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …

Proteomic profiling of brain cell types using isolation-based strategies pose limitations in
resolving cellular phenotypes representative of their native state. We describe a mouse line …

Neuroimmune interactions mediate intercellular communication and underlie critical brain
functions. Microglia, CNS-resident macrophages, modulate the brain through direct physical …

The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target
for protein misfolding neurodegenerative diseases, in which its overactivation results in …

Re-creating features of the native extracellular matrix (ECM) with engineered biomaterials
has become a valuable tool to probe the influence of ECM properties on cellular functions …

Spatial multi-omic studies have emerged as a promising approach to comprehensively
analyze cells in tissues, enabling the joint analysis of multiple data modalities like …

Microglial cells perform a plethora of functions in the central nervous system (CNS),
involving them in brain development, maintenance of homeostasis in adulthood, and CNS …

Cell-selective proteomics is a powerful emerging concept to study heterocellular processes
in tissues. However, its high potential to identify non-cell-autonomous disease mechanisms …