Tumour metastasis, the movement of tumour cells from a primary site to progressively
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …

Metabolic adaptations play a key role in fueling tumor growth. However, less is known
regarding the metabolic changes that promote cancer progression to metastatic disease …

LIM domain containing proteins are important regulators of diverse cellular processes, and
play pivotal roles in regulating the actin cytoskeleton. Lipoma Preferred Partner (LPP) is a …

Fluorescence illumination can cause phototoxicity that negatively affects living samples. This
study demonstrates that much of the phototoxicity and photobleaching experienced with live …

We have previously shown that lipoma preferred partner (LPP) mediates TGFβ-induced
breast cancer cell migration and invasion. Herein, we demonstrate that diminished LPP …

Glycoprotein nmb (GPNMB) promotes breast tumor growth and metastasis and its
expression in tumor epithelium correlates with poor prognosis in breast cancer patients …

Pancreatic ductal adenocarcinomas are highly malignant cancers characterized by
extensive invasion into surrounding tissues, metastasis to distant organs, and a limited …

Background Estrogen receptor β (ERβ) is expressed in the majority of invasive breast cancer
cases, irrespective of their subtype, including triple-negative breast cancer (TNBC). Thus …

ShcA is an important mediator of ErbB2-and transforming growth factor β (TGF-β)-induced
breast cancer cell migration, invasion, and metastasis. We show that in the context of …

SHC adaptor protein (SHCA) and lipoma-preferred partner (LPP) mediate transforming
growth factor β (TGFβ)-induced breast cancer cell migration and invasion. Reduced …