Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Recently, optical stimulation,, has begun to unravel the neuronal processing that controls
certain animal behaviours,. However, optical approaches are limited by the inability of …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

The microtubules that comprise mitotic spindles in animal cells are nucleated at
centrosomes and by spindle assembly factors that are activated in the vicinity of chromatin …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …

Chromosome segregation in mammalian oocytes is driven by a microtubule spindle lacking
centrosomes. Here, we analyze centrosome-independent spindle assembly by quantitative …

The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer
amplicon and is also overexpressed in colorectal, pancreatic and gastric tumours. Although …