Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Genome-wide association studies have identified 240 independent loci associated with type
2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast …

The diagnosis and treatment of congenital hyperinsulinism (CHI) have made a remarkable
progress over the past 20 years and, currently, it is relatively rare to see patients who are left …

Pancreatic beta-cells are the only cells in the body that can synthesize and secrete insulin.
Through the process of glucose-stimulated insulin secretion, beta-cells release insulin into …

The importance of glucokinase (GK) in the regulation of insulin secretion has been
highlighted by the phenotypes of individuals with activating and inactivating mutations in the …

Carnivores, such as the dolphin and the domestic cat, have numerous adaptations that befit
consumption of diets with high protein and fat content, with little carbohydrate content …

Glucokinase (GK) is a glucose-phosphorylating enzyme that regulates insulin release and
hepatic metabolism, and its loss of function is implicated in diabetes pathogenesis. GK …

Understanding how cell subpopulations in a tissue impact overall system function is
challenging. There is extensive heterogeneity among insulin-secreting β-cells within islets of …

Glucose homeostasis requires appropriate and synchronous coordination of metabolic
events and hormonal activities to keep plasma glucose concentrations in a narrow range of …