Massive segmental bone defects (SBD) are mostly treated by removing the fibula and
transplanting it complete with blood supply. While revolutionary 50 years ago, this remains …

Abstract Development of biocompatible porous supports is a promising strategy in the field
of tissue engineering for the repair and regeneration of bone tissues with severe damage …

Critically engineered stiffness and strength of a scaffold are crucial for managing
maladapted stress concentration and reducing stress shielding. At the same time, suitable …

The evolution of meta-biomaterials has opened up exciting new opportunities for mass
personalisation of biomedical devices. This research paper details the development of a …

Introduction Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the
difficulties in the fabrication of scaffolds with personalized structures still limited their clinical …

Background Bone defects remain challenging to manage. The wide array of treatment
options is a testament no single strategy works in every patient. This is more complex if …

Porous scaffolds have evolved, allowing personalised 3D-printed structures that can
improve tissue reconstruction. By using scaffolds with specific porosity, Poisson's ratio and …

Platelet-rich plasma (PRP) has been significantly important in oral and maxillofacial surgery
as it is rich in growth factors and can promote bone healing. However, its clinical efficacy …

Mesenchymal stem cells are core to bone homeostasis and repair. They both provide the
progenitor cells from which bone cells are formed and regulate the local cytokine …

Aim: To assess the efficacy of a bioregenerative scaffold derived from bone marrow aspirate,
cancellous bone autograft, platelet-rich plasma and autologous fibrin in treating …