LPA receptor signaling: pharmacology, physiology, and pathophysiology

YC Yung, NC Stoddard, J Chun - Journal of lipid research, 2014 - ASBMB
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2

RG Pertwee, AC Howlett, ME Abood… - Pharmacological …, 2010 - ASPET
There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy

H Kawanabe-Matsuda, K Takeda, M Nakamura… - Cancer Discovery, 2022 - AACR
Microbes and their byproducts have been reported to regulate host health and immune
functions. Here we demonstrated that microbial exopolysaccharide produced by …

LPA receptors: subtypes and biological actions

JW Choi, DR Herr, K Noguchi, YC Yung… - Annual review of …, 2010 - annualreviews.org
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

Y Kihara, M Maceyka, S Spiegel… - British journal of …, 2014 - Wiley Online Library
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands

AP Davenport, SPH Alexander, JL Sharman… - Pharmacological …, 2013 - ASPET
In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor
Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human …

[HTML][HTML] Plasmalogens, platelet-activating factor and beyond–Ether lipids in signaling and neurodegeneration

F Dorninger, S Forss-Petter, I Wimmer, J Berger - Neurobiology of disease, 2020 - Elsevier
Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids
that in mammals require peroxisomes for their biosynthesis. They are major components of …

International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature

J Chun, T Hla, KR Lynch, S Spiegel… - Pharmacological …, 2010 - ASPET
Lysophospholipids are cell membrane-derived lipids that include both glycerophospholipids
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate …

From peroxisomal disorders to common neurodegenerative diseases–the role of ether phospholipids in the nervous system

F Dorninger, S Forss‐Petter, J Berger - FEBS letters, 2017 - Wiley Online Library
The emerging diverse roles of ether (phospho) lipids in nervous system development and
function in health and disease are currently attracting growing interest. Plasmalogens, a …

Autotaxin: structure-function and signaling

A Perrakis, WH Moolenaar - Journal of lipid research, 2014 - ASBMB
Autotaxin (ATX), or ecto-nucleotide pyrophosphatase/phosphodiesterase-2, is a secreted
lysophospholipase D (lysoPLD) that hydrolyzes extracellular lysophospholipids into the lipid …