Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by
pain, decline in function and reduced exercise tolerance. The most common overuse …

Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …

Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and
characterization of their heterocellular relationships remains incomplete. Using mass …

Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …

The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and
sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes …

Background Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis,
inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and represent …

Abnormal activation of synovial fibroblasts (SFs) plays an important role in rheumatoid
arthritis (RA), the mechanism of which remains unknown. The purpose of our study is to …

Abstract Interleukin (IL)-11 evolved as part of the innate immune response. In the human
lung, IL-11 upregulation has been associated with viral infections and a range of …

MicroRNAs (miRNAs), a class of endogenous single-stranded short noncoding RNAs, have
emerged as vital epigenetic regulators of both pathological and physiological processes in …

Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and
impaired quality of life and no curative treatments exist. Increasing evidence indicates that …