Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases
T Lei, X Zhang, G Fu, S Luo, Z Zhao, S Deng… - Ageing Research …, 2024 - Elsevier
The prevalence of neurodegenerative diseases (NDs) is increasing rapidly as the aging
population accelerates, and there are still no treatments to halt or reverse the progression of …
population accelerates, and there are still no treatments to halt or reverse the progression of …
Using cortical organoids to understand the pathogenesis of malformations of cortical development
Malformations of cortical development encompass a broad range of disorders associated
with abnormalities in corticogenesis. Widespread abnormalities in neuronal formation or …
with abnormalities in corticogenesis. Widespread abnormalities in neuronal formation or …
[HTML][HTML] Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
NK Dhaliwal, OY Weng, X Dong, A Bhattacharya… - Cell Reports, 2024 - cell.com
Mutations in the phosphatase and tensin homolog (PTEN) gene are associated with severe
neurodevelopmental disorders. Loss of PTEN leads to hyperactivation of the mechanistic …
neurodevelopmental disorders. Loss of PTEN leads to hyperactivation of the mechanistic …