Neuronal persistent activity has been primarily assessed in terms of electrical mechanisms,
without attention to the complex array of molecular events that also control cell excitability …

Motivation Astrocytes, the most abundant glial cells in the mammalian brain, have an
instrumental role in developing neuronal circuits. They contribute to the physical structuring …

A large number of physiomic pathologies can produce hyperexcitability in cortex. Depending
on severity, cortical hyperexcitability may manifest clinically as a hyperkinetic movement …

Ultraliser is a neuroscience-specific software framework capable of creating accurate and
biologically realistic 3D models of complex neuroscientific structures at intracellular (eg …

Calcium () waves provide a complement to neuronal electrical signaling, forming a key part
of a neuron's second messenger system. We developed a reaction-diffusion model of an …

Generating realistic and complex computational domains for numerical simulations is often a
challenging task. In neuroscientific research, more and more one-dimensional morphology …

Neurons come in a wide variety of shapes and sizes. In a quest to understand this neuronal
diversity, researchers have three-dimensionally traced tens of thousands of neurons; many …

Understanding the intracellular dynamics of brain cells entails performing three-dimensional
molecular simulations incorporating ultrastructural models that can capture cellular …

For decades, neurons have been modeled by methods developed by early pioneers in the
field such as Rall, Hodgkin and Huxley, as cable-like morphological structures with voltage …

Creating high-quality polygonal meshes which represent the membrane surface of neurons
for both visualization and numerical simulation purposes is an important yet nontrivial task …