[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …
neurodegenerative disorders that are thought to exist on a clinical and pathological …
Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
A Tarutani, T Adachi, H Akatsu, Y Hashizume… - Acta …, 2022 - Springer
Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …
Targeting an RNA-binding protein network in acute myeloid leukemia
RNA-binding proteins (RBPs) are essential modulators of transcription and translation
frequently dysregulated in cancer. We systematically interrogated RBP dependencies in …
frequently dysregulated in cancer. We systematically interrogated RBP dependencies in …
[HTML][HTML] RBM33 is a unique m6A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity
Regulation of RNA substrate selectivity of m 6 A demethylase ALKBH5 remains elusive.
Here, we identify RNA-binding motif protein 33 (RBM33) as a previously unrecognized m 6 …
Here, we identify RNA-binding motif protein 33 (RBM33) as a previously unrecognized m 6 …
PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis
ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins discovered
nearly six decades ago, but many important questions remain regarding its molecular …
nearly six decades ago, but many important questions remain regarding its molecular …
Loss of dynamic RNA interaction and aberrant phase separation induced by two distinct types of ALS/FTD-linked FUS mutations
FUS is a nuclear RNA-binding protein, and its cytoplasmic aggregation is a pathogenic
signature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It …
signature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It …
[HTML][HTML] RNA-binding proteins in amyotrophic lateral sclerosis
M Zhao, JR Kim, R van Bruggen, J Park - Molecules and cells, 2018 - Elsevier
Significant research efforts are ongoing to elucidate the complex molecular mechanisms
underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential …
underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential …
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously
expressed regulators of RNA processing. To understand the molecular impact of ALS …
expressed regulators of RNA processing. To understand the molecular impact of ALS …
Genetic convergence brings clarity to the enigmatic red line in ALS
C Cook, L Petrucelli - Neuron, 2019 - cell.com
Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that
orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries …
orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries …
Cytoplasmic functions of TDP-43 and FUS and their role in ALS
TAR DNA-binding protein of 43 kDa (TDP-43) and fused in sarcoma (FUS) are RNA binding
proteins (RBPs) primarily located in the nucleus, and involved in numerous aspects of RNA …
proteins (RBPs) primarily located in the nucleus, and involved in numerous aspects of RNA …