Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

WS Lee, AK Wheatley, SJ Kent, BJ DeKosky - Nature microbiology, 2020 - nature.com
Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data …

Antibody tests for identification of current and past infection with SARS‐CoV‐2

T Fox, J Geppert, J Dinnes, K Scandrett… - Cochrane database …, 2022 - cochranelibrary.com
Background The diagnostic challenges associated with the COVID‐19 pandemic resulted in
rapid development of diagnostic test methods for detecting SARS‐CoV‐2 infection. Serology …

Protocol and reagents for pseudotyping lentiviral particles with SARS-CoV-2 spike protein for neutralization assays

KHD Crawford, R Eguia, AS Dingens, AN Loes… - Viruses, 2020 - mdpi.com
SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing
antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated …

A serological assay to detect SARS-CoV-2 seroconversion in humans

F Amanat, D Stadlbauer, S Strohmeier, THO Nguyen… - Nature medicine, 2020 - nature.com
Here, we describe a serological enzyme-linked immunosorbent assay for the screening and
identification of human SARS-CoV-2 seroconverters. This assay does not require the …

COVID-19 antibody tests and their limitations

G Liu, JF Rusling - ACS sensors, 2021 - ACS Publications
COVID-19, caused by the SARS-CoV-2 virus, has developed into a global health crisis,
causing over 2 million deaths and changing people's daily life the world over. Current main …

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

AE Muruato, CR Fontes-Garfias, P Ren… - Nature …, 2020 - nature.com
Virus neutralization remains the gold standard for determining antibody efficacy. Therefore,
a high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently …

[HTML][HTML] Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses

JT Ladner, SN Henson, AS Boyle… - Cell Reports …, 2021 - cell.com
The SARS-CoV-2 proteome shares regions of conservation with endemic human
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …

Evaluation and comparison of serological methods for COVID-19 diagnosis

F Gong, H Wei, Q Li, L Liu, B Li - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The worldwide pandemic of COVID-19 has become a global public health crisis. Various
clinical diagnosis methods have been developed to distinguish COVID-19–infected patients …

Serologic cross-reactivity of SARS-CoV-2 with endemic and seasonal Betacoronaviruses

J Hicks, C Klumpp-Thomas, H Kalish… - Journal of clinical …, 2021 - Springer
In order to properly understand the spread of SARS-CoV-2 infection and development of
humoral immunity, researchers have evaluated the presence of serum antibodies of people …

SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings

PCM Williams, AR Howard-Jones, P Hsu… - Pathology, 2020 - Elsevier
As the SARS-CoV-2 pandemic unfolds across the globe, consistent themes are emerging
with regard to aspects of SARS-CoV-2 infection and its associated disease entities in …