In fungi, the methylcitrate cycle converts cytotoxic propionyl-coenzyme A (CoA) to pyruvate,
which enters gluconeogenesis. The glyoxylate cycle converts acetyl-CoA to succinate, which …

Paracoccidioidomycosis (PCM) is a life-threatening systemic infection caused by the fungal
pathogen Paracoccidioides brasiliensis and related species. Whole-genome sequencing …

Members of the Paracoccidioides complex are the causative agents of
Paracoccidioidomycosis (PCM), a human systemic mycosis endemic in Latin America. Upon …

Emerging fungal pathogens are a global challenge for humankind. Many efforts have been
made to understand the mechanisms underlying pathogenicity in bacteria, and OMICs …

Histoplasma experiences nutritional stress during infection as a result of immune cells
manipulating essential nutrients, such as metal ions, carbon, nitrogen, and vitamins. Copper …

Candida albicans is a part of the normal microbiome of human mucosa and is able to thrive
in a wide range of host environments. As an opportunistic pathogen, the virulence of C …

Cobalamin is a cofactor present in essential metabolic pathways in animals and one of the
water-soluble vitamins. It is a complex compound synthesized solely by prokaryotes …

Microbial natural products have had phenomenal success in drug discovery and
development yet form distinct classes based on the origin of their native producer. Methods …

The pathogenicity of a common phytopathogenic bacterium, Pseudomonas syringae,
against animal model hosts, such as mice and Caenorhabditis elegans, has been recently …

Paracoccidioidomycosis (PCM) is a systemic mycosis, endemic in Latin America, caused by
fungi of the genus Paracoccidioides. The treatment of PCM is complex, requiring a long …