From the realization that cell number homoeostasis is fundamental to the biology of all
metazoans, and that deregulation of this process leads to human diseases, enormous …

In the plant kingdom, events of whole genome duplication or polyploidization are generally
believed to occur via alterations of the sexual reproduction process. Thereby, diploid pollen …

Ploidy increase has been shown to occur in different type of tumors and participate in tumor
initiation and resistance to the treatment. Polyploid giant cancer cells (PGCCs) are cells with …

Glioblastoma, WHO grade IV astrocytoma, is the most aggressive type of brain tumors.
These cancerous cells have a rapid growth rate, tendency to penetrate vital brain structures …

Induction of senescence has been proposed as a possible in vivo tumor response to
anticancer treatment. Senescent cancer cells are often polyploid, however, their route to …

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor.
Patients diagnosed with GBM have a poor prognosis, and it has been reported that tumor …

Objectives To explore the genetic and molecular events that control subclones exhibiting
distinct invasive/migratory capacities derived from human epithelial ovarian cancer (EOC) …

Survivin is a 16.5 kDa protein that functions to inhibit apoptosis, promote proliferation, and
enhance invasion. Absent in most adult tissues, survivin is selectively upregulated in many …

Barrett's oesophagus is the eponym used to describe the change from the normal stratified,
squamous epithelium of the lower oesophagus to a polarised, columnar-lined epithelium …

Survivin is a well-established target in experimental cancer therapy. The molecule is over-
expressed in most human tumors, but hardly detectable in normal tissues. Multiple functions …