The role of glutathione in cancer

GK Balendiran, R Dabur… - Cell Biochemistry and …, 2004 - Wiley Online Library
Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is
highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It …

Toxicity of amphetamines: an update

M Carvalho, H Carmo, VM Costa, JP Capela… - Archives of …, 2012 - Springer
Amphetamines represent a class of psychotropic compounds, widely abused for their
stimulant, euphoric, anorectic, and, in some cases, emphathogenic, entactogenic, and …

Human cancer cell antiproliferative and antioxidant activities of Juglans regia L.

M Carvalho, PJ Ferreira, VS Mendes, R Silva… - Food and chemical …, 2010 - Elsevier
Several studies suggest that regular consumption of nuts, mostly walnuts, may have
beneficial effects against oxidative stress mediated diseases such as cardiovascular …

Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models

HY Tiong, P Huang, S Xiong, Y Li… - Molecular …, 2014 - ACS Publications
The kidney is a major target for drug-induced toxicity. Drug-induced nephrotoxicity remains a
major problem in the clinical setting, where the use of nephrotoxic drugs is often …

Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity

JPE Spencer, MM Abd El Mohsen… - Archives of biochemistry …, 2004 - Elsevier
Flavonoids have been proposed to act as beneficial agents in a multitude of disease states,
including cancer, cardiovascular disease, and neurodegenerative disorders. The biological …

Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview

JP Capela, H Carmo, F Remião, ML Bastos… - Molecular …, 2009 - Springer
Abstract “Ecstasy”[(±)-3, 4-methylenedioxymethamphetamine, MDMA, XTC, X, E] is a
psychoactive recreational hallucinogenic substance and a major worldwide drug of abuse …

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites

JPE Spencer, GGC Kuhnle, RJ Williams… - Biochemical …, 2003 - portlandpress.com
Understanding the cellular effects of flavonoid metabolites is important for predicting which
dietary flavonoids might be most beneficial in vivo. Here we investigate the bioactivity in …

Biological activities of Portuguese propolis: protection against free radical-induced erythrocyte damage and inhibition of human renal cancer cell growth in vitro

MJ Valente, AF Baltazar, R Henrique… - Food and Chemical …, 2011 - Elsevier
This study reports for the first time the biological properties of Portuguese propolis. The
antioxidant potential of propolis samples from Bornes (Northeast) and Fundão (Centre) …

Acute toxic kidney injury

N Petejova, A Martinek, J Zadrazil, V Teplan - Renal failure, 2019 - Taylor & Francis
Substances toxic to the kidney are legion in the modern world. The sheer number and
variety, their mutual interactions and, metabolism within the body are a challenge to …

ADMET evaluation in drug discovery. 18. Reliable prediction of chemical-induced urinary tract toxicity by boosting machine learning approaches

T Lei, H Sun, Y Kang, F Zhu, H Liu, W Zhou… - Molecular …, 2017 - ACS Publications
Xenobiotic chemicals and their metabolites are mainly excreted out of our bodies by the
urinary tract through the urine. Chemical-induced urinary tract toxicity is one of the main …