Adapting to stress: understanding the neurobiology of resilience
There is significant variation in the way individuals react and respond to extreme stress and
adversity. While some individuals develop psychiatric conditions such as posttraumatic …
adversity. While some individuals develop psychiatric conditions such as posttraumatic …
To predict, prevent, and manage post-traumatic stress disorder (PTSD): a review of pathophysiology, treatment, and biomarkers
Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling
condition resulting in a reduced quality of life and increased economic burden. The disorder …
condition resulting in a reduced quality of life and increased economic burden. The disorder …
Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders
SJ Tsai - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Neurotrophins have been implicated in the pathophysiology of many neuropsychiatric
diseases. Brain-derived neurotrophic factor (BDNF) is the most abundant and widely …
diseases. Brain-derived neurotrophic factor (BDNF) is the most abundant and widely …
The genetics and epigenetics of PTSD: overview, recent advances, and future directions
Highlights•Over 100 candidate gene studies have been conducted to date.•Candidate gene
studies of the HPA-axis system appear to be promising.•Genome-wide association studies …
studies of the HPA-axis system appear to be promising.•Genome-wide association studies …
A Case‐Control Study and Meta‐Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD
Posttraumatic stress disorder (PTSD) is a debilitating condition that develops in some
people after exposure to a traumatic event. Brain‐derived neurotrophic factor (BDNF) is …
people after exposure to a traumatic event. Brain‐derived neurotrophic factor (BDNF) is …
The BDNF Val66Met polymorphism moderates the relationship between posttraumatic stress disorder and fear extinction learning
The low expression Met allele of the BDNF Val66Met polymorphism is associated with
impaired fear extinction in healthy controls, and poorer response to exposure therapy in …
impaired fear extinction in healthy controls, and poorer response to exposure therapy in …
Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness
Interaction between childhood trauma and genetic factors influences the pathophysiology of
posttraumatic stress disorder (PTSD). This study examined the interaction effect of childhood …
posttraumatic stress disorder (PTSD). This study examined the interaction effect of childhood …
BDNF Val66Met genotype and adolescent glucocorticoid treatment induce sex-specific disruptions to fear extinction and amygdala GABAergic interneuron expression …
S Raju, M Notaras, AM Grech, A Schroeder… - Hormones and …, 2022 - Elsevier
Abstract Background The BDNF Val66Met single nucleotide polymorphism has been
implicated in stress sensitivity and Post-Traumatic Stress Disorder (PTSD) risk. We …
implicated in stress sensitivity and Post-Traumatic Stress Disorder (PTSD) risk. We …
Genetic variants of the brain-derived neurotrophic factor and metabolic indices in veterans with posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is a trauma and stressor related disorder that may
develop after exposure to an event that involved the actual or possible threat of death …
develop after exposure to an event that involved the actual or possible threat of death …
The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder
Dysregulated consolidation of emotional memories is a core feature of posttraumatic stress
disorder (PTSD). Brain Derived Neurotrophic Factor (BDNF) influences synaptic plasticity …
disorder (PTSD). Brain Derived Neurotrophic Factor (BDNF) influences synaptic plasticity …