Role of hydrazine-related chemicals in cancer and neurodegenerative disease

PS Spencer, GE Kisby - Chemical Research in Toxicology, 2021 - ACS Publications
Hydrazine-related chemicals (HRCs) with carcinogenic and neurotoxic potential are found in
certain mushrooms and plants used for food and in products employed in various industries …

Unraveling the mysteries of MGMT: Implications for neuroendocrine tumors

J Xu, S Ji, X Yu, J Chen - Biochimica et Biophysica Acta (BBA)-Reviews …, 2024 - Elsevier
Neuroendocrine tumors (NETs) are a diverse group of tumors that arise from
neuroendocrine cells and are commonly found in various organs. A considerable proportion …

A Biomimetic Nanomedicine Targets Orthotopic Glioblastoma by Combinatorial Co‐Delivery of Temozolomide and a Methylguanine‐DNA Methyltransferase Inhibitor

Y Wang, Y Sun, N Geng, M Zheng… - Advanced …, 2022 - Wiley Online Library
Glioblastoma (GBM) is the most aggressive intracranial tumor that occurs in the central
nervous system (CNS) and has no effective treatment due to the fact of drug resistance. To …

Prognostic value of O6-methylguanine-DNA methyltransferase methylation in isocitrate dehydrogenase mutant gliomas

K Lam, BSC Eldred, B Kevan, S Pianka… - Neuro-oncology …, 2022 - academic.oup.com
Background Patients with isocitrate dehydrogenase (IDH) mutant gliomas have been
associated with longer survival time than those that are IDH wild-type. Previous studies have …

A novel DNA biosensor for the ultrasensitive detection of DNA methyltransferase activity based on a high-density “hot spot” SERS substrate and rolling circle …

S Ge, M Ran, Y Mao, Y Sun, X Zhou, L Li, X Cao - Analyst, 2021 - pubs.rsc.org
Herein, we proposed a novel biosensor based on a high-density “hot spot” Au@ SiO2 array
substrate and rolling circle amplification (RCA) strategy for the ultrasensitive detection of …

MGMT, a risk factor for both genetic and environmental forms of dementia

GE Kisby, H Oakes, D Beckett… - Alzheimer's & …, 2023 - Wiley Online Library
MGMT, the gene coding for the DNA‐repair protein O6‐methylguanine methyltransferase,
which has been recently shown to be a risk factor for inherited forms of Alzheimer's disease …

Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study

AP Kulkarni, G Hwang, CJ Cook… - Human Brain …, 2023 - Wiley Online Library
We propose a unique, minimal assumption, approach based on variance analyses
(compared with standard approaches) to investigate genetic influence on individual …

[HTML][HTML] Identifying genetic variants regulating MGMT gene expression-A study in monozygotic Danish twins

A Mohammadnejad, M Soerensen, J Mengel-From… - Genomics, 2023 - Elsevier
Identifying genetic factors affecting the regulation of the O-6-Methylguanine-DNA
Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene …

[PDF][PDF] MGMT promoter methylation status using droplet digital PCR in glioma patients: association with treatment response and survival

S Patel, N Bhalala, K Panchal, P Trivedi… - Int J All Res Edu Sci …, 2021 - researchgate.net
An epigenetic control mechanism plays a crucial role in natural and disease processes. The
common epigenetic mechanisms comprise DNA methylation. Aberrant DNA methylation is …

Restoring the Sphingolipid Balance in Glioblastoma

CC Hawkins - 2022 - search.proquest.com
Glioblastoma (GBM) is a highly aggressive brain tumor with a median survival of 15 months
even with standard of care—surgical resection, radiotherapy, and chemotherapy. Two of the …