The development of cutting-edge techniques to study specific brain regions and neural
circuits that regulate sleep–wake brain states and general anesthesia (GA), has increased …

Sleep has a homeostatic role in the regulation of the immune system and serves to constrain
activation of inflammatory signalling and expression of cellular inflammation. In patients with …

Diet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via
its influence on immunity and metabolism, caloric restriction and fasting appear to be …

Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …

Exercise, stress, sleep and diet are four distinct but intertwined lifestyle factors that influence
the cardiovascular system. Abundant epidemiological, clinical and preclinical studies have …

Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …

Sleep is integral to cardiovascular health 1, 2. Yet, the circuits that connect cardiovascular
pathology and sleep are incompletely understood. It remains unclear whether cardiac injury …

Chronic and uncleared inflammation is the root cause of various cardiovascular diseases.
Fundamentally, acute inflammation is supportive when overlapping with safe clearance of …

Chronologic age is the dominant risk factor for coronary artery disease but the features of
aging promoting coronary artery disease are poorly understood. Advances in human …

The mechanistic target of rapamycin (mTOR) is evolutionarily conserved from yeast to
humans and is one of the most fundamental pathways of living organisms. Since its …