Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …

Nitrogenase harbors three distinct metal prosthetic groups that are required for its activity.
The simplest one is a [4Fe-4S] cluster located at the Fe protein nitrogenase component. The …

Nitrogenases are responsible for biological nitrogen fixation, a crucial step in the
biogeochemical nitrogen cycle. These enzymes utilize a two-component protein system and …

Biological nitrogen fixation is catalyzed by the enzyme nitrogenase, which facilitates the
cleavage of the relatively inert triple bond of N2. Nitrogenase is most commonly associated …

If the atmosphere of the early Earth was hydrogen-rich, 1 it is reasonable to think that
hydrogenases, the enzymes enabling cells to use molecular hydrogen, were probably …

▪ Abstract Iron-sulfur [Fe-S] clusters are ubiquitous and evolutionary ancient prosthetic
groups that are required to sustain fundamental life processes. Owing to their remarkable …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

The chemical biology of thiols (RSH, eg, cysteine and cysteine‐containing
proteins/peptides) has been a topic of extreme interest for many decades due to their …

During the past century, chemists have sought economical methods of fixing atmospheric
dinitrogen for use as fertilizer, explosives, and other chemicals. Despite the simplicity of the …

Rhizobia induce nodule formation on legume roots and differentiate into bacteroids, which
catabolize plant-derived dicarboxylates to reduce atmospheric N2 into ammonia. Despite …