Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …
breaks in mammalian cells, the defining step of which is homologous strand exchange …
Repair of strand breaks by homologous recombination
M Jasin, R Rothstein - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
E Petermann, ML Orta, N Issaeva, N Schultz… - Molecular cell, 2010 - cell.com
Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs,
which initially results in stalled replication forks that, after prolonged treatment, collapse into …
which initially results in stalled replication forks that, after prolonged treatment, collapse into …
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
AJ Pierce, RD Johnson, LH Thompson… - Genes & …, 1999 - genesdev.cshlp.org
Homology-directed repair of DNA damage has recently emerged as a major mechanism for
the maintenance of genomic integrity in mammalian cells. The highly conserved strand …
the maintenance of genomic integrity in mammalian cells. The highly conserved strand …
Chromosomal stability and the DNA double-stranded break connection
DC Van Gent, JHJ Hoeijmakers, R Kanaar - Nature Reviews Genetics, 2001 - nature.com
Genome stability is of primary importance for the survival and proper functioning of all
organisms. Double-stranded breaks in DNA are important threats to genome integrity …
organisms. Double-stranded breaks in DNA are important threats to genome integrity …
BRCA2 is required for homology-directed repair of chromosomal breaks
ME Moynahan, AJ Pierce, M Jasin - Molecular cell, 2001 - cell.com
The BRCA2 tumor suppressor has been implicated in the maintenance of chromosomal
stability through a function in DNA repair. In this report, we examine human and mouse cell …
stability through a function in DNA repair. In this report, we examine human and mouse cell …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
DNA strand exchange and RecA homologs in meiosis
Homology search and DNA strand–exchange reactions are central to homologous
recombination in meiosis. During meiosis, these processes are regulated such that the …
recombination in meiosis. During meiosis, these processes are regulated such that the …
The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
A Bhattacharyya, UYS Ear, BH Koller… - Journal of Biological …, 2000 - ASBMB
Mutations in breast cancer tumor susceptibility genes, BRCA1 and BRCA2, predispose
women to early onset breast cancer and other malignancies. The Brca genes are involved in …
women to early onset breast cancer and other malignancies. The Brca genes are involved in …
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
E Sonoda, H Hochegger, A Saberi, Y Taniguchi… - DNA repair, 2006 - Elsevier
Repair of DNA double strand breaks (DSBs) plays a critical role in the maintenance of the
genome. DSB arise frequently as a consequence of replication fork stalling and also due to …
genome. DSB arise frequently as a consequence of replication fork stalling and also due to …