Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis
point to distinct immunological pathways that drive disease relapses and progression. In …

A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …

Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We
investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with …

Multiple sclerosis is a chronic inflammatory disease with primary demyelination and
neurodegeneration in the central nervous system. In our study we analysed demyelination …

Multiple sclerosis (MS) can be divided into four phenotypes based on clinical evolution. The
pathophysiological boundaries of these phenotypes are unclear, limiting treatment …

Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How
do different image acquisition parameters, fiber tracking algorithms and other …

MS is heterogeneous with respect to clinical, genetic, radiographic, and pathologic features;
surrogate MRI, clinical, genetic, serologic, and/or CSF markers for each of the four …

Objective Thalamic volume is a candidate magnetic resonance imaging (MRI)‐based
marker associated with neurodegeneration to hasten development of neuroprotective …

In multiple sclerosis (MS), diffuse degenerative processes in the deep grey matter have
been associated with clinical disabilities. We performed a systematic study in MS deep grey …

Learning a novel motor skill is associated with well characterized structural and functional
plasticity in the rodent motor cortex. Furthermore, neuroimaging studies of visuomotor …