Overlapping genes in natural and engineered genomes

BW Wright, MP Molloy, PR Jaschke - Nature Reviews Genetics, 2022 - nature.com
Modern genome-scale methods that identify new genes, such as proteogenomics and
ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open …

The role of stress proteins in haloarchaea and their adaptive response to environmental shifts

L Matarredona, M Camacho, B Zafrilla, MJ Bonete… - Biomolecules, 2020 - mdpi.com
Over the years, in order to survive in their natural environment, microbial communities have
acquired adaptations to nonoptimal growth conditions. These shifts are usually related to …

Isolation of a virus causing a chronic infection in the archaeal model organism Haloferax volcanii reveals antiviral activities of a provirus

T Alarcón-Schumacher, A Naor… - Proceedings of the …, 2022 - National Acad Sciences
Viruses are important ecological, biogeochemical, and evolutionary drivers in every
environment. Upon infection, they often cause the lysis of the host cell. However, some …

Ribosome profiling in archaea reveals leaderless translation, novel translational initiation sites, and ribosome pausing at single codon resolution

DR Gelsinger, E Dallon, R Reddy… - Nucleic acids …, 2020 - academic.oup.com
High-throughput methods, such as ribosome profiling, have revealed the complexity of
translation regulation in Bacteria and Eukarya with large-scale effects on cellular functions …

Carotenoids as a Protection Mechanism against Oxidative Stress in Haloferax mediterranei

M Giani, RM Martínez-Espinosa - Antioxidants, 2020 - mdpi.com
Haloarchaea are extremophilic microorganisms that in their natural ecosystem encounter
several sources of oxidative stress. They have developed different strategies to cope with …

The archaeal protein SepF is essential for cell division in Haloferax volcanii

P Nußbaum, M Gerstner, M Dingethal, C Erb… - Nature …, 2021 - nature.com
In most bacteria, cell division depends on the tubulin homolog FtsZ and other proteins, such
as SepF, that form a complex termed the divisome. Cell division also depends on FtsZ in …

A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities

RK Hackley, A Vreugdenhil-Hayslette, CL Darnell… - Plos …, 2024 - journals.plos.org
Timely regulation of carbon metabolic pathways is essential for cellular processes and to
prevent futile cycling of intracellular metabolites. In Halobacterium salinarum, a hypersaline …

Small RNAs as fundamental players in the transference of information during bacterial infectious diseases

JJ González Plaza - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
Communication shapes life on Earth. Transference of information has played a paramount
role on the evolution of all living or extinct organisms since the appearance of life. Success …

Genome-wide transcriptional response to silver stress in extremely halophilic archaeon Haloferax alexandrinus DSM 27206 T

DM Buda, E Szekeres, LB Tudoran, J Esclapez… - BMC microbiology, 2023 - Springer
Background The extremely halophilic archaeon Haloferax (Hfx.) alexandrinus DSM 27206 T
was previously documented for the ability to biosynthesize silver nanoparticles while …

Characterization of the transcriptome of Haloferax volcanii, grown under four different conditions, with mixed RNA-Seq

S Laass, VA Monzon, J Kliemt, M Hammelmann… - PLoS …, 2019 - journals.plos.org
Haloferax volcanii is a well-established model species for haloarchaea. Small scale
RNomics and bioinformatics predictions were used to identify small non-coding RNAs …