Fungal endophytes: A promising frontier for discovery of novel bioactive compounds

MM Gakuubi, M Munusamy, ZX Liang, SB Ng - Journal of fungi, 2021 - mdpi.com
For years, fungi have served as repositories of bioactive secondary metabolites that form the
backbone of many existing drugs. With the global rise in infections associated with …

Natural products discovery and potential for new antibiotics

O Genilloud - Current opinion in microbiology, 2019 - Elsevier
Microbial natural products have been one of the most important sources for the discovery of
potential new antibiotics. However, the decline in the number of new chemical scaffolds …

An insight into endophytic antimicrobial compounds: An updated analysis

S Digra, S Nonzom - Plant Biotechnology Reports, 2023 - Springer
Resistance in micro-organisms against antimicrobial compounds is an emerging
phenomenon in the modern era as compared to the traditional world which brings new …

Bioactive compounds from mangrove endophytic fungus and their uses for microorganism control

RD Cadamuro, IMA da Silveira Bastos, IT Silva… - Journal of fungi, 2021 - mdpi.com
Mangroves are ecosystems with unique characteristics due to the high salinity and amount
of organic matter that house a rich biodiversity. Fungi have aroused much interest as they …

Marine pharmacology in 2018: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; …

AMS Mayer, ML Pierce, K Howe, AD Rodríguez… - Pharmacological …, 2022 - Elsevier
The 2018 marine pharmacology literature review represents a continuation of the previous
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …

Chromatin-dependent regulation of secondary metabolite biosynthesis in fungi: is the picture complete?

J Collemare, MF Seidl - FEMS microbiology reviews, 2019 - academic.oup.com
Fungal secondary metabolites are small molecules that exhibit diverse biological activities
exploited in medicine, industry and agriculture. Their biosynthesis is governed by co …

How to completely squeeze a fungus—advanced genome mining tools for novel bioactive substances

A Schüller, L Studt-Reinhold, J Strauss - Pharmaceutics, 2022 - mdpi.com
Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …

Epigenetic Manipulation Induced Production of Immunosuppressive Chromones and Cytochalasins from the Mangrove Endophytic Fungus Phomopsis asparagi DHS …

T Feng, C Wei, X Deng, D Chen, Z Wen, J Xu - Marine Drugs, 2022 - mdpi.com
A mangrove endophytic fungus Phomopsis asparagi DHS-48 was found to be particularly
productive with regard to the accumulation of substantial new compounds in our previous …

Spongian Diterpenoids Derived from the Antarctic Sponge Dendrilla antarctica Are Potent Inhibitors of the Leishmania Parasite

AJ Shilling, CG Witowski, JA Maschek… - Journal of natural …, 2020 - ACS Publications
From the CH2Cl2 extract of the Antarctic sponge Dendrilla antarctica we found spongian
diterpenes, including previously reported aplysulphurin (1), tetrahydroaplysulphurin-1 (2) …

[HTML][HTML] Anti-infectives from mangrove endophytic fungi

SK Deshmukh, S Agrawal, V Prakash, MK Gupta… - South African Journal of …, 2020 - Elsevier
Endophytic fungi reside within the plant tissues and maintain a strong symbiotic relationship.
They are of utmost importance as promising sources of chemically diverse bioactive natural …