Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Enhancers are genomic sequences that play a key role in regulating tissue-specific gene
expression levels. An increasing number of diseases are linked to impaired enhancer …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Epigenetics has been defined as 'the structural adaptation of chromosomal regions so as to
register, signal or perpetuate altered activity states.'Currently, several classes of anticancer …

The bromodomain and extraterminal (BET) protein Brd4 recruits transcriptional regulatory
complexes to acetylated chromatin. While Brd4 is considered to be a general transcriptional …

Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why
inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells …

Following the discovery of BRD4 as a non-oncogene addiction target in acute myeloid
leukaemia (AML),, bromodomain and extra terminal protein (BET) inhibitors are being …

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic
options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results …