Objective To investigate disease spread in amyotrophic lateral sclerosis (ALS), and
determine the influence of lower (LMN) and upper motor neuron (UMN) involvement …

Background Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease with a median survival of 2–5 years. An early diagnosis is essential for providing …

Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative
disease with unsatisfactory treatment options. Best management and recruitment into clinical …

Objective Amyotrophic lateral sclerosis (ALS) pathogenesis is still unclear, its course is
considerably variable, and prognosis is hard to determine. Despite much research, there is …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease mainly affecting upper
and lower motor neurons in the brain and spinal cord. Pathogenesis of ALS is still unclear …

Background The role of cardiovascular risk factors in amyotrophic lateral sclerosis (ALS) is
controversial. A favourable profile has been found in ALS patients, but previous studies have …

Background and purpose Amyotrophic lateral sclerosis (ALS) is increasingly recognized as
a multisystem disorder with 30%–50% of patients exhibiting cognitive impairment. The …

Objective: To study disease characteristics, progression and outcome in a group of motor
neuron disease (MND) patients beginning with frontotemporal dementia (FTD) by comparing …

Objectives: High-intensity physical activity and sports prone to repetitive injuries of the
cervical spine and head (when associated with vigorous practice) have been suggested as …

Objective: The flail-arm syndrome (FAS), one of the Amyotrophic lateral sclerosis (ALS)
phenotypes, is characterized by slow progression and predominantly lower motor neuron …