Cryptococcus neoformans Infection in the Central Nervous System: The Battle between Host and Pathogen

Y Chen, ZW Shi, AB Strickland, M Shi - Journal of Fungi, 2022 - mdpi.com
Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

Mechanisms of fungal dissemination

AB Strickland, M Shi - Cellular and Molecular Life Sciences, 2021 - Springer
Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier

J Kim, KT Lee, JS Lee, J Shin, B Cui, K Yang… - Nature biomedical …, 2021 - nature.com
The neurovascular unit, which consists of vascular cells surrounded by astrocytic end-feet
and neurons, controls cerebral blood flow and the permeability of the blood–brain barrier …

Mechanisms of pathogen invasion into the central nervous system

MD Cain, H Salimi, MS Diamond, RS Klein - Neuron, 2019 - cell.com
CNS infections continue to rise in incidence in conjunction with increases in
immunocompromised populations or conditions that contribute to the emergence of …

Central nervous system cryptococcal infections in non-HIV infected patients

J Beardsley, TC Sorrell, SCA Chen - Journal of Fungi, 2019 - mdpi.com
Central nervous system (CNS) cryptococcosis in non-HIV infected patients affects solid
organ transplant (SOT) recipients, patients with malignancy, rheumatic disorders, other …

Microglia are not protective against cryptococcal meningitis

SH Mohamed, MS Fu, S Hain, A Alselami… - Nature …, 2023 - nature.com
Microglia provide protection against a range of brain infections including bacteria, viruses
and parasites, but how these glial cells respond to fungal brain infections is poorly …

Animal Models of Cryptococcus neoformans in Identifying Immune Parameters Associated With Primary Infection and Reactivation of Latent Infection

TG Normile, AM Bryan, M Del Poeta - Frontiers in Immunology, 2020 - frontiersin.org
Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus

NM Walsh, MR Botts, AJ McDermott, SC Ortiz… - PLoS …, 2019 - journals.plos.org
The majority of invasive human fungal pathogens gain access to their human hosts via the
inhalation of spores from the environment into the lung, but relatively little is known about …

Neuroimaging of cryptococcal meningitis in patients without human immunodeficiency virus: data from a multi-center cohort study

SH Anjum, JE Bennett, O Dean, KA Marr… - Journal of Fungi, 2023 - mdpi.com
Background: A clearer understanding is needed about the use of brain MRI in non-HIV
patients with cryptococcal meningitis. Methods: Cerebral CT and MRI were studied in 62 …

Purinergic signaling in infectious diseases of the central nervous system

VS Alves, R Leite-Aguiar, JP da Silva… - Brain, Behavior, and …, 2020 - Elsevier
The incidence of infectious diseases affecting the central nervous system (CNS) has been
increasing over the last several years. Among the reasons for the expansion of these …