GSK‐3 is a ubiquitously expressed serine/threonine kinase existing as GSK‐3α and GSK‐
3β isoforms, both active under basal conditions and inactivated upon phosphorylation by …

Cancer is the second most fatal disease worldwide, with colon cancer being the third most
prevalent and fatal form of cancer in several Western countries. The risk of acquisition of …

Ferroptosis is a newly discovered form of regulated cell death and characterized by an iron-
dependent accumulation of lethal lipid reactive oxygen species (ROS), ferroptosis may …

We have previously reported that the differentiation-inducing factor-1 (DIF-1), a compound
identified in Dictyostelium discoideum, suppresses the growth of MCF-7 breast cancer cells …

Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which
is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is …

Abstract Aims Differentiation-inducing factor-1 (DIF-1), a compound in Dictyostelium
discoideum, exhibits anti-cancer effects by inhibiting cell proliferation and motility of various …

Simple Summary The incidence of cutaneous melanoma is increasing worldwide, currently
responsible for 287,723 new cases and 60,712 deaths per year (GLOBOCAN, IARC, WHO) …

The social amoeba Dictyostelium discoideum has been a preferred model organism during
the last 50 years, particularly for the study of cell motility and chemotaxis, phagocytosis and …

Recently, irreversible inhibitors have attracted great interest in antitumors due to their
advantages of forming covalent bonds to target proteins. Herein, some benzothiazepinone …

Fibrosis occurs in all organs and tissues except the brain, and its progression leads to
dysfunction of affected organs. Fibrosis-induced organ dysfunction results from the loss of …