The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

The neuroimmune mechanism underlying neuropathic pain has been extensively studied.
Tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine that drives cytokine …

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric
population and are often treated with lifesaving chemotherapy. However, chemotherapy …

Disclosures: K. Schroder reported" other" from Inflazome Ltd outside the submitted work; in
addition, K. Schroder had a patent to PCT/EP2017/053498 licensed (Inflazome Ltd), a patent …

There is a pressing need for more effective nonaddictive treatment options for pain. Pain
signals are transmitted from the periphery into the spinal cord via dorsal root ganglion (DRG) …

Background Neuroinflammation plays an important role in the pathogenesis of glaucoma.
Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine released from …

Objective Axonal excitability reflects ion channel function, and it is proposed that this may be
a biomarker in painful (vs painless) polyneuropathy. Our objective was to investigate the …

Vincristine and bortezomib are effective chemotherapeutics widely used to treat
hematological cancers. Vincristine blocks tubulin polymerization, whereas bortezomib is a …

Neuropathic pain in children can be severe and persistent, difficult to recognise and
manage, and associated with significant pain-related disability. Recognition based on …

Between 1989 and 1990, two independent research groups of anatomists and histologists at
the Karolinska Institute of Stockholm, Sweden, showed that antibodies against the …