Accumulating evidence over the past three decades suggests that altered calcium signaling
during development may be a major driving force for adult pathophysiological events. Well …

Mesendodermal specification is one of the earliest events in embryogenesis, where cells
first acquire distinct identities. Cell differentiation is a highly regulated process that involves …

Multiple cell types and complex connection networks are an intrinsic feature of brain tissue.
In this study we used expression profiling of specific microscopic regions of heterogeneous …

The specialized sensory organs of the vertebrate head are derived from thickened patches
of cells in the ectoderm called cranial sensory placodes. The developmental program that …

Sox11, a member of the SoxC family of transcription factors, has distinct functions at different
times in neural development. Studies in mouse, frog, chick, and zebrafish show that Sox11 …

Temporal regulation of super-enhancer (SE) driven transcription factors (TFs) underlies
normal developmental programs. Neuroblastoma (NB) arises from an inability of …

Precisely controlled dendrite morphogenesis ensures proper neural circuit assembly and
neural network integrity during development. In the cerebral cortex, dendrite morphogenesis …

During neurogenesis, transcription factors (TFs) regulate each cellular transition from cell
cycle exit, to neuronal differentiation and eventual maturation, ensuring that the correct …

Neurogenesis is a tightly controlled developmental process through which neural progenitor
cells progress to committed neurons. While the SoxB1 transcription factors are well …

During neurogenesis, the Sox transcription factors, maintain a balance of proliferating
progenitors and differentiating neurons. While a number of studies have demonstrated that …