Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the
nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent …

Nanopore RNA sequencing shows promise as a method for discriminating and identifying
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …

Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

Epigenetic drug discovery field has evidenced significant advancement in the recent times.
A plethora of small molecule inhibitors have progressed to clinical stage investigations and …

The ENCODE project has reported that at least 80% of the human genome is biologically
active, yet only a small part of human DNA encodes for protein. The massive amount of RNA …

Post-transcriptional modification of RNA nucleosides occurs in all living organisms.
Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the …

Small nucleolar RNAs (SnoRNAs) are a class of non-coding RNAs divided into two classes:
C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA …

Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …

Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous
elements in the production of the protein synthesis machinery of the cell. Recently, however …