Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Anemia of inflammation (AI), also known as anemia of chronic disease (ACD), is regarded
as the most frequent anemia in hospitalized and chronically ill patients. It is prevalent in …

Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled
intestinal iron absorption may lead to progressive iron overload (IO) responsible for …

Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …

Iron is an essential element for numerous fundamental biologic processes, but excess iron is
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …

Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however,
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …

Ferritin is considered the major iron storage protein which maintains a large iron core in its
cavity and has ferroxidase activity. There are many types of ferritin particularly in prokaryotes …

Iron is required for the survival of most organisms, including bacteria, plants, and humans. Its
homeostasis in mammals must be fine-tuned to avoid iron deficiency with a reduced oxygen …

Iron is a constituent of many metalloproteins involved in vital metabolic functions. While
adequate iron supply is critical for health, accumulation of excess iron promotes oxidative …

Iron is an essential micronutrient that is problematic for biological systems since it is toxic as
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …