Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division …

The concept that cancer is a metabolic disease is now well acknowledged: many cancer cell
types rely mostly on glucose and some amino acids, especially glutamine for energy supply …

Amino acids are indispensable nutrients for both normal and cancer cells. Cancer cells are
unable to synthesize essential amino acids as well as some non‐essential amino acids …

The large neutral amino acid transporter 1 (LAT1, or SLC7A5) is a sodium-and pH-
independent transporter, which supplies essential amino acids (eg, leucine, phenylalanine) …

Amino acids (AAs) are necessary nutrients which act not only as building blocks in protein
synthesis but also in crucial anabolic cellular signaling pathways. It has been demonstrated …

Simple Summary ASCT2 and LAT1 are amino acid transporters whose impact in cancer has
been explored throughout the years. They have been associated with most currently …

LAT1 is a member of the system L transporter family. The main role of the LAT1 is to
transport specific amino acids through cell membranes to provide nutrients to cells and …

L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into
cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) …

Cancer cells are usually featured by metabolic adaptations that facilitate their growth,
invasion, and metastasis. Thus, reprogramming of intracellular energy metabolism is …