Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth
muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the …

Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix
deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as …

Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal
organs in the context of autoimmunity and vascular perturbation. Overproduction of …

Heterogeneity in systemic sclerosis (SSc) confounds clinical trials. We previously identified
“intrinsic” gene expression subsets by analysis of SSc skin. Here we test the hypotheses that …

Systemic sclerosis (SSc) is a debilitating inflammatory and fibrotic disease that affects the
skin and internal organs. Although the pathophysiology of SSc remains poorly …

Skin biopsy gene expression was analyzed by DNA microarray from 13 diffuse cutaneous
systemic sclerosis (dSSc) patients enrolled in an open-label study of rituximab, 9 dSSc …

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and
organ fibrosis. The pathogenesis of SSc and its progression are poorly understood. The SSc …

Mice bearing a “humanized” immune system are valuable tools to experimentally
manipulate human cells in vivo and facilitate disease models not normally possible in …