Chalcone derivatives: anti-inflammatory potential and molecular targets perspectives

DK Mahapatra, SK Bharti, V Asati - Current topics in medicinal …, 2017 - ingentaconnect.com
Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold has gained considerable scientific
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …

Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor κb activities

H ur Rashid, Y Xu, N Ahmad, Y Muhammad… - Bioorganic Chemistry, 2019 - Elsevier
Abstract Chalcones (1, 3-Diphenyl-2-propen-1-one) consist of a three carbon α, β-
unsaturated carbonyl system and act as precursors for the biosynthesis of flavonoids in …

Prenylation enhances the biological activity of dietary flavonoids by altering their bioavailability

R Mukai - Bioscience, Biotechnology, and Biochemistry, 2018 - academic.oup.com
Flavonoids are distributed across the plant kingdom and have attracted substantial attention
owing to their potential benefits for human health. Several studies have demonstrated that …

Aurones: synthesis and properties

AV Popova, SP Bondarenko, MS Frasinyuk - Chemistry of Heterocyclic …, 2019 - Springer
This article provides generalized and systematic overview of data on the synthesis,
stereoisomerism, and reactivity of aurones (2-benzylidenebenzofuran-3 (2 Н)-ones) …

Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages

K Rullah, NF Shamsudin, A Koeberle… - Future medicinal …, 2024 - Taylor & Francis
Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes
has been explored for the treatment of inflammation and inflammation-related disorders …

An overview of synthetic and semisynthetic flavonoid derivatives and analogues: perspectives in drug discovery

V Uivarosi, AC Munteanu, GM Nițulescu - Studies in Natural Products …, 2019 - Elsevier
As a result of their outstanding structural diversity, flavonoids are known to exhibit a wide
range of pharmacological properties, including antioxidant, antitumor, antimicrobial …

Coenzyme Q10-loaded fish oil-based bigel system: probing the delivery across porcine skin and possible interaction with fish oil fatty acids

MH Zulfakar, LM Chan, K Rehman, LK Wai… - Aaps Pharmscitech, 2018 - Springer
Abstract Coenzyme Q10 (CoQ10) is a vitamin-like oil-soluble molecule that has anti-oxidant
and anti-ageing effects. To determine the most optimal CoQ10 delivery vehicle, CoQ10 was …

A review of the various synthetic approaches to access aurone derivatives and their biological activities

E Lathwal, S Kumar - Current Organic Chemistry, 2023 - ingentaconnect.com
Aurones, a member of the flavonoid family, have limited occurrence in nature and are
relatively less explored than other flavonoids but still constitute a gleaming class of …

Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents

EB Park, KJ Kim, HR Jeong, JK Lee, HJ Kim… - Bioorganic & Medicinal …, 2016 - Elsevier
In our previous research, a novel series of phenylsulfonyl hydrazide derivatives were found
to reduce LPS-induced PGE 2 levels in RAW 264.7 macrophage cells via an inhibition of …

Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones

K Rullah, MFF Mohd Aluwi, BM Yamin… - Asian Journal of …, 2019 - Wiley Online Library
In this Minireview, we discuss some of the important palladium‐catalysed cross‐coupling
reactions utilised in the synthesis of the enone system of chalcones. Examples given here …