Nearly all functions of the human body are organized across the 24 hours of the day. This is
also true for functions involved in the regulation of pharmacokinetics such as gastric …

Sleep disturbances are frequently reported in victims following burn injuries. This
prospective study was designed to assess sleep quality and to examine its daily relationship …

Pain is a major socioeconomic and health problem in the world. There is no unique medical
term that can encompass the vast reach of the condition, from acute surgery-related …

Biological rhythms and their temporal organization are adaptive phenomena to periodic
changes in environmental factors linked to the earth's rotation on its axis and around the …

The authors define a subject as euchronic when the circadian parameters—tau (τ= period),
Ø (acrophse or peak time), A (amplitude), and M (MESOR= 24 h rhythm‐adjusted mean)—of …

About four decades ago, Perl and collaborators were the first ones who unambiguously
identified specifically nociceptive neurons in the periphery. In their classic work, they …

Background. Circadian variation may affect many biological and pharmacological
phenomena. Methods. To assess circadian variations in labour pain perception, 222 …

Two experiments examined the influence of time of day on the intravenous self-
administration of cocaine and its associated pharmacokinetic profile in male Sprague …

Circadian rhythms in the body are well established and are an important factor to consider
when administering drugs. Many diseases display symptoms and onset characteristics that …

Biological processes and functions at all hierarchical levels are organized in time as
biological rhythms of discrete periods. Circadian (24-hour) rhythms, which are of direct …