Lamin-binding proteins
A-and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in
a plethora of stable and transient interactions, near the inner nuclear membrane and …
a plethora of stable and transient interactions, near the inner nuclear membrane and …
Nuclear mechanics in disease
M Zwerger, CY Ho, J Lammerding - Annual review of biomedical …, 2011 - annualreviews.org
Over the past two decades, the biomechanical properties of cells have emerged as key
players in a broad range of cellular functions, including migration, proliferation, and …
players in a broad range of cellular functions, including migration, proliferation, and …
A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)
E Giorgio, D Robyr, M Spielmann… - Human molecular …, 2015 - academic.oup.com
Chromosomal rearrangements with duplication of the lamin B1 (LMNB1) gene underlie
autosomal dominant adult-onset demyelinating leukodystrophy (ADLD), a rare neurological …
autosomal dominant adult-onset demyelinating leukodystrophy (ADLD), a rare neurological …
The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina
Oligodendrocytes are specialized cells that insulate and support axons with their myelin
membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as …
membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as …
Partners and post-translational modifications of nuclear lamins
DN Simon, KL Wilson - Chromosoma, 2013 - Springer
Nuclear intermediate filament networks formed by A-and B-type lamins are major
components of the nucleoskeleton that are required for nuclear structure and function, with …
components of the nucleoskeleton that are required for nuclear structure and function, with …
Direct actin binding to A-and B-type lamin tails and actin filament bundling by the lamin A tail
DN Simon, MS Zastrow, KL Wilson - Nucleus, 2010 - Taylor & Francis
Nuclear intermediate filament networks formed by A-and B-type lamins are major
components of the nucleoskeleton. Lamins have growing links to human physiology and …
components of the nucleoskeleton. Lamins have growing links to human physiology and …
[HTML][HTML] Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts
The architecture and structural mechanics of the cell nucleus are defined by the nuclear
lamina, which is formed by A-and B-type lamins. Recently, gene duplication and protein …
lamina, which is formed by A-and B-type lamins. Recently, gene duplication and protein …
Understanding the ultra-rare disease autosomal dominant leukodystrophy: An updated review on morpho-functional alterations found in experimental models
I Neri, G Ramazzotti, S Mongiorgi, I Rusciano… - Molecular …, 2023 - Springer
Autosomal dominant leukodystrophy (ADLD) is an ultra-rare, slowly progressive, and fatal
neurodegenerative disorder associated with the loss of white matter in the central nervous …
neurodegenerative disorder associated with the loss of white matter in the central nervous …
Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis
S Mahajani, C Giacomini, F Marinaro… - Scientific reports, 2017 - nature.com
Lamin B1, a key component of the nuclear lamina, plays an important role in brain
development. Ablation of endogenous Lamin B1 (Lmnb1) in the mouse strongly impairs …
development. Ablation of endogenous Lamin B1 (Lmnb1) in the mouse strongly impairs …
Emerging cellular themes in leukodystrophies
JC Nowacki, AM Fields, MM Fu - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Leukodystrophies are a broad spectrum of neurological disorders that are characterized
primarily by deficiencies in myelin formation. Clinical manifestations of leukodystrophies …
primarily by deficiencies in myelin formation. Clinical manifestations of leukodystrophies …