Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Bitopic integral membrane proteins with a single transmembrane helix play diverse roles in
catalysis, cell signaling, and morphogenesis. Complete monospanning protein structures …

Abstract The order Chaetothyriales (Pezizomycotina, Ascomycetes) harbours obligatorily
melanised fungi and includes numerous etiologic agents of chromoblastomycosis …

Much of the information on the Cytochrome P450 enzymes (CYPs) is spread across
literature and the internet. Aggregating knowledge about CYPs into one database makes the …

Infections by fungal pathogens such as Candida albicans and Aspergillus fumigatus and
their resistance to triazole drugs are major concerns. Fungal lanosterol 14α-demethylase …

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and
treatments for superficial and disseminated fungal infections, but cure rates are not optimal …

Surgical face masks are the most popularised and effective personal equipment for
protecting public health during the COVID-19 pandemic. They are composed of plastic …

The efficiency of treatment of human infections with the unicellular eukaryotic pathogens
such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates …

Multicellular organisms developed the concept of specialized cells that perform specific
functions. Examples are neurons and fibroblast to name just two out of more than 200 …