Alterations to genes involved in cellular metabolism and epigenetic regulation are
implicated in the pathogenesis of myeloid malignancies. Recurring mutations in isocitrate …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …

Somatic mutations acquired in healthy tissues as we age are major determinants of cancer
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …

We present a phase II, single-arm study evaluating 800 mg daily venetoclax, a highly
selective, oral small-molecule B-cell leukemia/lymphoma-2 (BCL2) inhibitor in patients with …

In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of
initiating lesions, and order of subsequent mutations remain poorly understood, as AML is …

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …

Somatic mutations commonly occur in hematopoietic stem cells (HSCs). Some mutant
clones outgrow through clonal hematopoiesis (CH) and produce mutated immune progenies …

Cellular ROS production participates in various cellular functions but its accumulation
decides the cell fate. Malignant cells have higher levels of ROS and active antioxidant …

Mutant isocitrate dehydrogenase (IDH) 1 and 2 proteins alter the epigenetic landscape in
acute myeloid leukemia (AML) cells through production of the oncometabolite (R)-2 …

Abstract Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation,
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …