In the relatively young but expanding field of irreversible kinase inhibitor drug discovery,
there are two main developments that are of central importance. First, the patients have …

Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be
considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres …

Vascular endothelial growth factor-2 (VEGFR-2) is considered one of the most important
factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have …

Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …

The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …

Abstract Machine learning is a well-known approach for virtual screening. Recently, deep
learning, a machine learning algorithm in artificial neural networks, has been applied to the …

Abstract Novel thieno [2, 3-d] pyrimidine analogues were designed, synthesized and
evaluated for anti-proliferative activity against HepG-2, PC-3 and MCF-7 cancer cell lines. In …

We present a fast and effective covalent docking approach suitable for large-scale virtual
screening (VS). We applied this method to four targets (HCV NS3 protease, Cathepsin K …

Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds.
They are important and widely represented in medicinal chemistry as they are structural …

A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4, 5, 6, 7-
tetrahydrobenzo [b] thiophene-3-carboxylate 1. An interesting cyclization was obtained …