Messenger RNA (mRNA) translation by the ribosome represents the final step of a
complicated molecular dance from DNA to protein. Although classically considered a …

The challenges to individuals with epilepsy extend far beyond the seizures. Co‐morbidities
in epilepsy are very common and are often more problematic to individuals than the seizures …

Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability,
impaired social development and persistent drug-resistant seizures. One of its primary …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Dravet syndrome combines clonic generalized, focal or unilateral seizures, beginning within
the first year of life, often triggered by hyperthermia whatever its cause, including pertussis …

In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …

Abstract Objective Individuals with Dravet syndrome (DS) experience frequent
pharmacoresistant seizures beginning in infancy. Most exhibit poor neurodevelopmental …

Dravet syndrome is a debilitating epileptic encephalopathy of childhood with few treatment
options available in the United States before 2018. In the modern era, new genetic testing …

Background and purpose Dravet syndrome (DS) is a severe, drug‐resistant epilepsy.
Fenfluramine has been reported to have a long‐term clinically meaningful anticonvulsive …

Objective Reducing levels of the microtubule‐associated protein tau has shown promise as
a potential treatment strategy for diseases with secondary epileptic features such as …