Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation

S Gimondi, H Ferreira, RL Reis, NM Neves - ACS nano, 2023 - ACS Publications
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

Biomedical applications of microfluidic devices: a review

G Gharib, İ Bütün, Z Muganlı, G Kozalak, İ Namlı… - Biosensors, 2022 - mdpi.com
Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids

E Prince, J Cruickshank, W Ba-Alawi… - Nature …, 2022 - nature.com
Patient-derived tumor organoids (PDOs) are a highly promising preclinical model that
recapitulates the histology, gene expression, and drug response of the donor patient tumor …

Biomaterial-based platforms for tumour tissue engineering

R Curvello, V Kast, P Ordóñez-Morán, A Mata… - Nature Reviews …, 2023 - nature.com
Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

A comprehensive review on 3D tissue models: biofabrication technologies and preclinical applications

R Xie, V Pal, Y Yu, X Lu, M Gao, S Liang, M Huang… - Biomaterials, 2024 - Elsevier
The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …

Trends in droplet microfluidics: From droplet generation to biomedical applications

Z Chen, S Kheiri, EWK Young, E Kumacheva - Langmuir, 2022 - ACS Publications
Over the past decade, droplet microfluidics has attracted growing interest in biology,
medicine, and engineering. In this feature article, we review the advances in droplet …

3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip

W Li, Z Zhou, X Zhou, BL Khoo… - Advanced …, 2023 - Wiley Online Library
Decades of efforts in engineering in vitro cancer models have advanced drug discovery and
the insight into cancer biology. However, the establishment of preclinical models that enable …

Recent methods of droplet microfluidics and their applications in spheroids and organoids

Y Wang, M Liu, Y Zhang, H Liu, L Han - Lab on a Chip, 2023 - pubs.rsc.org
Droplet microfluidic techniques have long been known as a high-throughput approach for
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …

Efficient Surfactant‐Mediated Photovoltaic Manipulation of fL‐Scale Aqueous Microdroplets for Diverse Optofluidic Applications on LiNbO3 Platform

Z Gao, J Yan, L Shi, X Liu, M Wang, C Li… - Advanced …, 2023 - Wiley Online Library
The electrodeless biocompatible manipulation of femtoliter‐scale aqueous microdroplets
remains challenging. The appropriate isolation of electrostatic charges from femtoliter‐scale …

A multifunctional nanocatalyst based on ultra-fluorescent carbon quantum dots for cascade enzymatic activity and stimuli-responsive chemotherapy of cancer

A Wibrianto, G Getachew, WB Dirersa, AS Rasal… - Carbon, 2023 - Elsevier
Clinical studies have switched from monotherapy to multimodal therapy due to the intricacy,
multiplicity, and unpredictability of malignant tumors. In this work, we report one-pot …