Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic
feature is persistent itching of the skin. The chronic, relapsing course of the disease …

In this Review we focus on the initiation of autoantibody production and autoantibody
pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular …

Adipose tissue inflammation mediates the association between excessive body fat
accumulation and several chronic inflammatory diseases. A high prevalence of obesity …

Asthma is a chronic airway inflammatory disease that is influenced by the interplay between
genetic factors and exposure to environmental allergens, microbes, or microbial products …

Control of cytokine production by immune cells is pivotal for counteracting infections via
orchestration of local and systemic inflammation. Although their contribution has long been …

Mast cells (MCs) are important sensor and effector cells of the immune system that are
involved in many physiological and pathological conditions. Increasing evidence suggests …

Purpose Osteoarthritis (OA) of the knee is a multifactorial degenerative disease typically
defined as the 'wear and tear'of articular joint cartilage. However, recent studies suggest that …

Since their establishment in 1981, RBL‐2H3 cells have been widely used as a mast cell
(MC) model. Their ability to be easily grown in culture in large amounts, their …

IgA is predominantly recognized to play an important role in host defense at mucosal sites,
where it prevents invasion of pathogens by neutralization. Although it has recently become …