Notch signaling: simplicity in design, versatility in function
Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …
stages during development. Notch signaling must therefore be able to generate appropriate …
[HTML][HTML] The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways
T Borggrefe, M Lauth, A Zwijsen, D Huylebroeck… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Notch signaling is a highly conserved signal transduction pathway that regulates stem cell
maintenance and differentiation in several organ systems. Upon activation, the Notch …
maintenance and differentiation in several organ systems. Upon activation, the Notch …
Notch signaling
R Kopan - Cold Spring Harbor perspectives in biology, 2012 - cshperspectives.cshlp.org
Notch Signaling Cold Spring Harbor Perspectives in Biology Skip to main page content HOME
ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE ALERTS FEEDBACK …
ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE ALERTS FEEDBACK …
Notch post-translationally regulates β-catenin protein in stem and progenitor cells
C Kwon, P Cheng, IN King, P Andersen, L Shenje… - Nature cell …, 2011 - nature.com
Cellular decisions of self-renewal or differentiation arise from integration and reciprocal
titration of numerous regulatory networks. Notch and Wnt/β-catenin signalling often intersect …
titration of numerous regulatory networks. Notch and Wnt/β-catenin signalling often intersect …
Non-canonical Notch signaling: emerging role and mechanism
P Andersen, H Uosaki, LT Shenje, C Kwon - Trends in cell biology, 2012 - cell.com
Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although
the 'canonical'Notch pathway and its core members are well established–involving ligand …
the 'canonical'Notch pathway and its core members are well established–involving ligand …
Wnt–Notch signalling crosstalk in development and disease
GM Collu, A Hidalgo-Sastre, K Brennan - Cellular and molecular life …, 2014 - Springer
Abstract The Notch and Wnt pathways are two of only a handful of highly conserved
signalling pathways that control cell-fate decisions during animal development (Pires …
signalling pathways that control cell-fate decisions during animal development (Pires …
Notch: the past, the present, and the future
S Artavanis-Tsakonas, MAT Muskavitch - Current topics in developmental …, 2010 - Elsevier
Proliferating investigations of the Notch pathway have given rise to the Notch “field,” which
has grown exponentially over the past 30 years. This field, founded by investigations of …
has grown exponentially over the past 30 years. This field, founded by investigations of …
[HTML][HTML] A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network
A Saj, Z Arziman, D Stempfle, W Van Belle, U Sauder… - Developmental cell, 2010 - cell.com
Notch signaling plays a fundamental role in cellular differentiation and has been linked to
human diseases, including cancer. We report the use of comprehensive RNAi analyses to …
human diseases, including cancer. We report the use of comprehensive RNAi analyses to …
[HTML][HTML] Notch: A multi-functional integrating system of microenvironmental signals
B LaFoya, JA Munroe, MM Mia, MA Detweiler… - Developmental …, 2016 - Elsevier
The Notch signaling cascade is an evolutionarily ancient system that allows cells to interact
with their microenvironmental neighbors through direct cell-cell interactions, thereby …
with their microenvironmental neighbors through direct cell-cell interactions, thereby …
Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting
M Di Piazza, CS Nowell, U Koch, AD Durham, F Radtke - Cancer cell, 2012 - cell.com
Inflammation can promote or inhibit cancer progression. In this study we have addressed the
role of the proinflammatory cytokine thymic stromal lymphopoietin (TSLP) during skin …
role of the proinflammatory cytokine thymic stromal lymphopoietin (TSLP) during skin …