The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is
organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically …

Although emerging evidence indicates that alterations in proteins within nuclear
compartments elicit changes in chromosomal architecture and differentiation, the underlying …

Spermatogenesis is a complex, multistep process that maintains male fertility and is
sustained by rare germline stem cells. Spermatogenic progression begins with …

The major vessels in mammals that take blood away from the heart and deliver it to the arms
and the head take their origin from the aortic arch and are derived from the arteries formed …

Bicuspid aortic valve (BAV) is the most common congenital heart defect. Although many BAV
patients remain asymptomatic, at least 20% develop thoracic aortic aneurysm (TAA) …

Abnormalities in nucleic acid processing are associated with the development of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin …

Chromosomal translocations, rearrangements involving the exchange of segments between
chromosomes, were documented in humans in 1959. The first accurately reported clinical …

Reactivation of fetal-specific genes and isoforms occurs during heart failure. However, the
underlying molecular mechanisms and the extent to which the fetal program switch occurs …

Background: Bicuspid aortic valve (BAV), the most common congenital heart defect affecting
1% to 2% of the population, is a major risk factor for premature aortic valve disease and …