Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Individualizing patient treatment is a core objective of the medical field. Reaching this
objective has been elusive owing to the complex set of factors contributing to both disease …

Understanding gene regulation and function requires a genome-wide method capable of
capturing both gene expression levels and isoform diversity at the single-cell level. Short …

Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells.
In this study, we document parallel regulation of CD8+ T cells and Foxp3+ Tregs by …

The cancer stem cell (CSC) concept has important therapeutic implications, but its
investigation has been hampered both by a lack of consistency in the terms used for these …

Mass cytometry facilitates high-dimensional, quantitative analysis of the effects of bioactive
molecules on human samples at single-cell resolution, but instruments process only one …

Cellular heterogeneity that arises from stochastic expression of genes, proteins and
metabolites is a fundamental principle of cell biology, but single cell analysis has been …

Efforts to discover new cancer drugs and predict their clinical activity are limited by the fact
that laboratory models to test drug efficacy do not faithfully recapitulate this complex disease …

Cytobank is a Web‐based application for storage, analysis, and sharing of flow cytometry
experiments. Researchers use a Web browser to log in and use a wide range of tools …

The development of single-cell methods for capturing different data modalities including
imaging and sequencing has revolutionized our ability to identify heterogeneous cell states …